Hydroxyl Radical Generation by the Combination of Iron and Ascorbic Acid is Greatly Attenuated but Still Significant in Human Gastric Juice.

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ascorbic acid: a factor concentrated in human gastric juice.

1. Concentrations of ascorbic acid (ascorbic and dehydro-ascorbic; A + D; measured by the 2,4-dinitrophenylhydrazine method) of nearly three times those of plasma are present in gastric juice samples from patients with normal gastric histology. 2. A significant reduction in gastric juice ascorbic acid (A + D) was observed in patients with chronic gastritis. This reduction in concentration was i...

متن کامل

Hydrogen peroxide and hydroxyl radical formation by methylene blue in the presence of ascorbic acid.

Using ESR we have demonstrated the formation of the ascorbate free radical from sodium ascorbate, methylene blue and light. In oxygen uptake experiments we have observed the production of hydrogen peroxide while spin trapping experiments have revealed the iron catalyzed production of the hydroxyl free radical in this system. The presence of this highly reactive radical suggests that it could be...

متن کامل

Human granulocyte generation of hydroxyl radical

Human granulocytes were capable of oxidizing 2-keto-4 thiomethylbutyric acid to ethylene during phagocytosis or membrane perturbation. The reaction required hydrogen peroxide and superoxide and in addition was inhibited by various hydroxyl radical (OH) scavengers. These observations represent direct evidence for the generation of OH by human granulocytes. Further, inhibition of ethylene generat...

متن کامل

The production of hydroxyl radical by bleomycin and iron (ii).

Bleomycin 1s a glycopeptidlc antlblotlc used for the treatment of cancer [l] . In vitro, a major effect of bleomycm 1s the mtroduction of strand breaks into DNA [2,3]. Efficient breakage of DNA by bleomycm requues the presence of reducing agents, such as 2-mercaptoethanol, dltiothreitol, ascorbate, or hydrogen peroxlde [3,4]. Although reducing agents alone are injurious to DNA [5,6], the combin...

متن کامل

Manganese-induced hydroxyl radical formation in rat striatum is not attenuated by dopamine depletion or iron chelation in vivo.

The present studies were aimed at investigating the possible roles of dopamine (DA) and iron in production of hydroxyl radicals (OH) in rat striatum after Mn2+ intoxication. For this purpose, DA depletions were assessed concomitant with in vivo 2,3- and 2,5-dihydroxybenzoic acid (DHBA) formation from the reaction of salicylate with OH, of which 2,3-DHBA is a nonenzymatic adduct. Following intra...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Internal Medicine

سال: 2002

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.41.1213